TY - JOUR
T1 - Platelets to surrogate lung inflammation in COVID-19 patients
AU - Kuchi Bhotla, Haripriya
AU - Kaul, Tanushri
AU - Balasubramanian, Balamuralikrishnan
AU - Easwaran, Murugesh
AU - Arumugam, Vijaya Anand
AU - Pappusamy, Manikantan
AU - Muthupandian, Saravanan
AU - Meyyazhagan, Arun
N1 - Funding Information:
The authors thank ICGEB authorities especially to the Director ICGEB, New Delhi for providing the necessary infrastructure and ICGEB core funds for this research work i.e. to analyze and screen the variants for COVID19 disease. We also thank Director-General, ICGEB Trieste, Italy and Department of Biotechnology (DBT) for supporting the research activities at ICGEB. We also thank Dr. K. Sasikala, Rtd. Professor and Emeritus, School of Life Science, Bharathiar University, Coimbatore ? 641046, India, and Dr. Suresh Easwaran, ENT Surgeon, Government Head Quarters Hospital, Kanchipuram, Tamil Nadu, India, for their valuable suggestions and discussions to write the manuscript. HKB, ME and TK have done the literature search and drafted the paper. AM, BB, and MS helped with the literature search and revised the manuscript. SC, MS put forward the hypothesis and revised the manuscript. VA, PM, HKB, ME, AM and BB provided ideas about the mechanism of platelet receptor interaction and revised the paper. All authors approved the final version of the hypothesis.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/10
Y1 - 2020/10
N2 - The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. The virus contagion predicted to have been originated from Wuhan, China has by far trapped 4,198,418 cases from 212 countries in the world with two international conveyances with 284,102 deaths as of 11 May 2020 (10:18 GMT). Researchers around the globe have indulged in deciphering viral mode in the body for devising a cure. Affirmations from autopsies and preliminary findings on SARS-CoV-2 hypothesized on viral pathogenesis within the host, for instance, source of inflammation in lungs and pneumonia. This hypothesis assigns the platelets as agents of infection after viral entry. Presently, curbing infection to stall the spread of SARS-CoV-2 is the prima facie intervention employed, worldwide. However, public health authorities must monitor the state of affairs scrupulously, as the deeper our understanding of this novel virus and its associated outbreak, the better we can deal with it. Knowing this idea might be far-fetched, yet this postulate would serve as the groundwork for the present situation.
AB - The neoteric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been jeopardizing the world with the symptoms of seasonal flu. The virus contagion predicted to have been originated from Wuhan, China has by far trapped 4,198,418 cases from 212 countries in the world with two international conveyances with 284,102 deaths as of 11 May 2020 (10:18 GMT). Researchers around the globe have indulged in deciphering viral mode in the body for devising a cure. Affirmations from autopsies and preliminary findings on SARS-CoV-2 hypothesized on viral pathogenesis within the host, for instance, source of inflammation in lungs and pneumonia. This hypothesis assigns the platelets as agents of infection after viral entry. Presently, curbing infection to stall the spread of SARS-CoV-2 is the prima facie intervention employed, worldwide. However, public health authorities must monitor the state of affairs scrupulously, as the deeper our understanding of this novel virus and its associated outbreak, the better we can deal with it. Knowing this idea might be far-fetched, yet this postulate would serve as the groundwork for the present situation.
KW - COVID-19
KW - Lung inflammation
KW - Pathogenesis
KW - Platelets
KW - Thrombocytopenia
UR - http://www.scopus.com/inward/record.url?scp=85088645549&partnerID=8YFLogxK
U2 - 10.1016/j.mehy.2020.110098
DO - 10.1016/j.mehy.2020.110098
M3 - Letter
C2 - 32688185
AN - SCOPUS:85088645549
SN - 0306-9877
VL - 143
JO - Medical Hypotheses
JF - Medical Hypotheses
M1 - 110098
ER -
