Genetic and non-genetic tailoring of microalgae for the enhanced production of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) – A review

Parul Jakhwal; Jayanta Kumar Biswas; Archana Tiwari; Eilhann E. Kwon; Amit Bhatnagar

doi:10.1016/j.biortech.2021.126250

Genetic and non-genetic tailoring of microalgae for the enhanced production of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) – A review

Parul Jakhwal, Jayanta Kumar Biswas, Archana Tiwari, Eilhann E. Kwon, Amit Bhatnagar

Department of Environment, Energy & Geoinformatics

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

The myriad health benefits associated with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) laid the path for their application in the functional foods and nutraceutical industries. Fish being primarily exploited for extraction of EPA and DHA are unsustainable sources; thus, oleaginous microalgae turn out to be an alternative sustainable source. This review paper aims to provide the recent developments in the context of enhancing EPA and DHA production by utilising non-genetic tailoring and genetic tailoring methods. We have also summarized the legislation, public perception, and possible risks associated with the usage of genetically modified microalgae focusing on EPA and DHA production.

Original language	English
Article number	126250
Journal	Bioresource Technology
Volume	344
DOIs	https://doi.org/10.1016/j.biortech.2021.126250
State	Published - Jan 2022

Keywords

Docosahexaenoic acid (DHA)
Eicosapentaenoic acid (EPA)
Genetic and non-genetic modification
Microalgae biorefinery
Photosynthetic efficiency

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10.1016/j.biortech.2021.126250

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title = "Genetic and non-genetic tailoring of microalgae for the enhanced production of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) – A review",

abstract = "The myriad health benefits associated with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) laid the path for their application in the functional foods and nutraceutical industries. Fish being primarily exploited for extraction of EPA and DHA are unsustainable sources; thus, oleaginous microalgae turn out to be an alternative sustainable source. This review paper aims to provide the recent developments in the context of enhancing EPA and DHA production by utilising non-genetic tailoring and genetic tailoring methods. We have also summarized the legislation, public perception, and possible risks associated with the usage of genetically modified microalgae focusing on EPA and DHA production.",

keywords = "Docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA), Genetic and non-genetic modification, Microalgae biorefinery, Photosynthetic efficiency",

author = "Parul Jakhwal and {Kumar Biswas}, Jayanta and Archana Tiwari and Kwon, {Eilhann E.} and Amit Bhatnagar",

note = "Funding Information: Figures 1, 3 and graphical abstract were prepared using BioRender. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2022",

month = jan,

doi = "10.1016/j.biortech.2021.126250",

language = "English",

volume = "344",

journal = "Bioresource Technology",

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AU - Kumar Biswas, Jayanta

AU - Tiwari, Archana

AU - Kwon, Eilhann E.

AU - Bhatnagar, Amit

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KW - Photosynthetic efficiency

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Genetic and non-genetic tailoring of microalgae for the enhanced production of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) – A review

Abstract

Keywords

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