Differential responses of human liver cancer and normal cells to atmospheric pressure plasma

Bomi Gweon; Mina Kim; Dan Bee Kim; Daeyeon Kim; Hyeonyu Kim; Heesoo Jung; Jennifer H. Shin; Wonho Choe

doi:10.1063/1.3622631

Differential responses of human liver cancer and normal cells to atmospheric pressure plasma

Bomi Gweon, Mina Kim, Dan Bee Kim, Daeyeon Kim, Hyeonyu Kim, Heesoo Jung, Jennifer H. Shin, Wonho Choe

Department of Mechanical Engineering

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

When treated by atmospheric pressure plasma, human liver cancer cells (SK-HEP-1) and normal cells (THLE-2) exhibited distinctive cellular responses, especially in relation to their adhesion behavior. We discovered the critical threshold voltage of 950 V, biased at the electrode of the micro-plasma jet source, above which SK-HEP-1 started to detach from the substrate while THLE-2 remained intact. Our mechanical and biochemical analyses confirmed the presence of intrinsic differences in the adhesion properties between the cancer and the normal liver cells, which provide a clue to the differential detachment characteristics of cancer and normal cells to the atmospheric pressure plasma.

Original language	English
Article number	063701
Journal	Applied Physics Letters
Volume	99
Issue number	6
DOIs	https://doi.org/10.1063/1.3622631
State	Published - 8 Aug 2011

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@article{88983f83898444cf8be95a9da4ab9095,

title = "Differential responses of human liver cancer and normal cells to atmospheric pressure plasma",

abstract = "When treated by atmospheric pressure plasma, human liver cancer cells (SK-HEP-1) and normal cells (THLE-2) exhibited distinctive cellular responses, especially in relation to their adhesion behavior. We discovered the critical threshold voltage of 950 V, biased at the electrode of the micro-plasma jet source, above which SK-HEP-1 started to detach from the substrate while THLE-2 remained intact. Our mechanical and biochemical analyses confirmed the presence of intrinsic differences in the adhesion properties between the cancer and the normal liver cells, which provide a clue to the differential detachment characteristics of cancer and normal cells to the atmospheric pressure plasma.",

author = "Bomi Gweon and Mina Kim and {Bee Kim}, Dan and Daeyeon Kim and Hyeonyu Kim and Heesoo Jung and Shin, {Jennifer H.} and Wonho Choe",

note = "Funding Information: The authors thank Wonjong Song, Sunghyun Kim, Unghyun Ko Sukhyun Song, Se Youn Moon, and Sunhee Kim for their initial contribution in experiments. This work was in part supported by KAIST.",

year = "2011",

month = aug,

day = "8",

doi = "10.1063/1.3622631",

language = "English",

volume = "99",

journal = "Applied Physics Letters",

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TY - JOUR

T1 - Differential responses of human liver cancer and normal cells to atmospheric pressure plasma

AU - Gweon, Bomi

AU - Kim, Mina

AU - Bee Kim, Dan

AU - Kim, Daeyeon

AU - Kim, Hyeonyu

AU - Jung, Heesoo

AU - Shin, Jennifer H.

AU - Choe, Wonho

N1 - Funding Information: The authors thank Wonjong Song, Sunghyun Kim, Unghyun Ko Sukhyun Song, Se Youn Moon, and Sunhee Kim for their initial contribution in experiments. This work was in part supported by KAIST.

PY - 2011/8/8

Y1 - 2011/8/8

N2 - When treated by atmospheric pressure plasma, human liver cancer cells (SK-HEP-1) and normal cells (THLE-2) exhibited distinctive cellular responses, especially in relation to their adhesion behavior. We discovered the critical threshold voltage of 950 V, biased at the electrode of the micro-plasma jet source, above which SK-HEP-1 started to detach from the substrate while THLE-2 remained intact. Our mechanical and biochemical analyses confirmed the presence of intrinsic differences in the adhesion properties between the cancer and the normal liver cells, which provide a clue to the differential detachment characteristics of cancer and normal cells to the atmospheric pressure plasma.

AB - When treated by atmospheric pressure plasma, human liver cancer cells (SK-HEP-1) and normal cells (THLE-2) exhibited distinctive cellular responses, especially in relation to their adhesion behavior. We discovered the critical threshold voltage of 950 V, biased at the electrode of the micro-plasma jet source, above which SK-HEP-1 started to detach from the substrate while THLE-2 remained intact. Our mechanical and biochemical analyses confirmed the presence of intrinsic differences in the adhesion properties between the cancer and the normal liver cells, which provide a clue to the differential detachment characteristics of cancer and normal cells to the atmospheric pressure plasma.

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U2 - 10.1063/1.3622631

DO - 10.1063/1.3622631

M3 - Review article

AN - SCOPUS:84860388947

SN - 0003-6951

VL - 99

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 6

M1 - 063701

ER -

Differential responses of human liver cancer and normal cells to atmospheric pressure plasma

Abstract

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