Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice

Hongwon Kim; Jaein Shin; Sumin Kim; Siyoung Kim; Byounggook Cho; Sang jun Park; Gwoncheol Park; Hakdong Shin; Myeong Soo Park; Jongpil Kim

doi:10.1016/j.bbrc.2022.03.024

Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice

Hongwon Kim, Jaein Shin, Sumin Kim, Siyoung Kim, Byounggook Cho, Sang jun Park, Gwoncheol Park, Hakdong Shin, Myeong Soo Park, Jongpil Kim

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

An increasing number of studies have indicated that alterations in gut microbiota affect brain function, including cognition and memory ability, via the gut-brain axis. In this study, we aimed to determine the protective effect of Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) on age-related brain damage in mice. We found that administration of B. bifidum BGN4 and B. longum BORI effectively elevates brain-derived neurotrophic factor expression which was mediated by increased histone 3 lysine 9 trimethylation. Furthermore, administration of probiotic supplementation reversed the DNA damage and apoptotic response in aged mice and also improved the age-related cognitive and memory deficits of these mice. Taken together, the present study highlights the anti-aging effects of B. bifidum BGN4 and B. longum BORI in the aged brain and their beneficial effects for age-related brain disorders.

Original language	English
Pages (from-to)	41-48
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	603
DOIs	https://doi.org/10.1016/j.bbrc.2022.03.024
State	Published - 7 May 2022

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Publisher Copyright:
© 2022 Elsevier Inc.

Keywords

Aging
Bifidobacterium
Cognitive and memory impairment
Gut microbiota
Probiotics

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title = "Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice",

abstract = "An increasing number of studies have indicated that alterations in gut microbiota affect brain function, including cognition and memory ability, via the gut-brain axis. In this study, we aimed to determine the protective effect of Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) on age-related brain damage in mice. We found that administration of B. bifidum BGN4 and B. longum BORI effectively elevates brain-derived neurotrophic factor expression which was mediated by increased histone 3 lysine 9 trimethylation. Furthermore, administration of probiotic supplementation reversed the DNA damage and apoptotic response in aged mice and also improved the age-related cognitive and memory deficits of these mice. Taken together, the present study highlights the anti-aging effects of B. bifidum BGN4 and B. longum BORI in the aged brain and their beneficial effects for age-related brain disorders.",

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doi = "10.1016/j.bbrc.2022.03.024",

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T1 - Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice

AU - Kim, Hongwon

AU - Shin, Jaein

AU - Kim, Sumin

AU - Kim, Siyoung

AU - Cho, Byounggook

AU - Park, Sang jun

AU - Park, Gwoncheol

AU - Shin, Hakdong

AU - Park, Myeong Soo

AU - Kim, Jongpil

PY - 2022/5/7

Y1 - 2022/5/7

N2 - An increasing number of studies have indicated that alterations in gut microbiota affect brain function, including cognition and memory ability, via the gut-brain axis. In this study, we aimed to determine the protective effect of Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) on age-related brain damage in mice. We found that administration of B. bifidum BGN4 and B. longum BORI effectively elevates brain-derived neurotrophic factor expression which was mediated by increased histone 3 lysine 9 trimethylation. Furthermore, administration of probiotic supplementation reversed the DNA damage and apoptotic response in aged mice and also improved the age-related cognitive and memory deficits of these mice. Taken together, the present study highlights the anti-aging effects of B. bifidum BGN4 and B. longum BORI in the aged brain and their beneficial effects for age-related brain disorders.

AB - An increasing number of studies have indicated that alterations in gut microbiota affect brain function, including cognition and memory ability, via the gut-brain axis. In this study, we aimed to determine the protective effect of Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) on age-related brain damage in mice. We found that administration of B. bifidum BGN4 and B. longum BORI effectively elevates brain-derived neurotrophic factor expression which was mediated by increased histone 3 lysine 9 trimethylation. Furthermore, administration of probiotic supplementation reversed the DNA damage and apoptotic response in aged mice and also improved the age-related cognitive and memory deficits of these mice. Taken together, the present study highlights the anti-aging effects of B. bifidum BGN4 and B. longum BORI in the aged brain and their beneficial effects for age-related brain disorders.

KW - Aging

KW - Bifidobacterium

KW - Cognitive and memory impairment

KW - Gut microbiota

KW - Probiotics

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JF - Biochemical and Biophysical Research Communications

ER -

Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI promotes neuronal rejuvenation in aged mice

Abstract

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